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Job No. 148601

  • Job Title:
  • RESEARCH FELLOW
  • Employer:
  • University of Michigan-Ann Arbor
  • Location:
  • Ann Arbor , MI
  • Posting Date:
  • 24-Jan-2023
  • Description:
  • Summary

    The Barmada & Mosalaganti Labs at the University of Michigan are looking for a postdoctoral research fellow to join their research team to establish faithful in vitro models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). You will leverage these models to recapitulate and investigate disease-associated patterns of protein aggregation, uncovering basic mechanisms of disease and paving the way for new biomarkers.

    The Barmada Lab has a long-standing interest in delineating the molecular underpinnings of ALS and FTD through a combination of neuroscience, molecular biology, genome engineering, longitudinal microscopy, and stem cell biology. In a complementary fashion, the Mosalaganti lab uses cryo-electron tomography, correlative light, and electron microscopy approaches to elucidate structure of disease-related protein complexes in situ.

    As a postdoctoral fellow, you will have unencumbered access to state-of-the-art equipment and microscopes located in the Department of Neurology and at the Life Sciences Institute, including a Leica Stellaris cryo-confocal, an Aquilos2, a Titan Krios G4i (with K3, Bioquantum imaging filter, and phase plate), and an Oxford Nanoimager. You will report directly to Drs. Mosalaganti and Barmada.


    Queries regarding the project must be directed to sbarmada@umich.edu or mosalaga@umich.edu.

    Mission Statement

    Our mission at the Life Sciences Institute is to advance the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health.

    For more information on the Life Sciences Institute: https://www.lsi.umich.edu/

    For more information on the Mosalaganti lab: https://www.lsi.umich.edu/science/our-labs/mosalaganti-lab

    For more information on the Department of Neurology: https://medicine.umich.edu/dept/neurology

    For more information on the Barmada lab: https://www.barmadalab.com/

    Responsibilities*

    Experimental responsibilities include:

    Culture, maintenance and differentiation of human induced pluripotent stem cells
    Primary cell isolation and culturing
    PCR and quantitative reverse transcriptase (qRT)-PCR
    Molecular cloning
    Genome editing (i.e., CRISPR/Cas9)
    Immunostaining
    Western blotting
    Fluorescence microscopy
    Quantitative data analysis of microscopy data
    Non-experimental responsibilities will include:

    Collaborate with students, postdoctoral fellows, and lab staff
    Oversee the training of new lab members
    Attendance and presentation at lab meetings and journal clubs
    Write papers and participate in discussions with both labs
    Required Qualifications*

    PhD (or equivalent) in cell biology, genetics or related discipline.
    2 years of experience in light and confocal microscopy (imaging/data processing)
    1 year of experience with primary cultures or stem cells
    Familiarity with computational biology and image based analyses
    Familiarity with CRISPR/Cas9 and molecular biology/cloning
    Work as a team player
    Experience in structural biology
    Additional Information

    In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:

    Many choices for comprehensive health insurance
    Dental and Vision Insurance
    Life insurance
    Long-term disability coverage
    Flexible spending accounts for healthcare and dependent care expenses
    Maternity and Parental Leave
    Background Screening

    The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.

    Application Deadline

    Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
  •  Contact information:
  • University of Michigan-Ann Arbor
  • Ann Arbor , MI 48109
  • United States
  • Employer's Website:
  • Visit Employer's website



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