| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 | Survey of Clinical Cases of Biomaterials-Tissue Interactions | Yannas/Spector | Introduction by Spector (PDF)
Introduction by Yannas (PDF) |
| L2 | Tissue Structures, Unit Cell Processes, and Integrins | Spector | Tools for Understanding the Molecular, Cellular, and Physiological, Bases of the Tissue Response to Implants (PDF)
Introduction: Tissue Types (PDF - 1.7 MB)
Unit Cell Processes (PDF)
Integrins (PDF) |
| L3 | Unit Cell Processes Comprising the Healing Response | Spector | UCPs in the Healing Environment (PDF)
Formation of Soft Tissue and Bone Around Implants: The Chronic Response to Implants (PDF) |
| L4 | Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs | Yannas | Irreversible Healing of Extracellular Matrix (PDF) |
| L5 | Biochemistry of the ECM | Yannas | Naturally Occuring ECMs: Collagen (PDF - 1.1 MB)
Naturally Occuring ECMs: Elastin, PG and GAG, CAM (PDF) |
| L6 | Scaffolds Based on ECM Analogs Used in Organ Synthesis | Yannas | Synthesis of Biologically Active Scaffolds (Regeneration Templates) (PDF) |
| L7 | Organ Replacement by Induced Regeneration and Tissue Engineering | Yannas/Spector | Tissue Engineering: Overview (PDF) |
| L8 | Principles and Practice of Tissue Engineering | Spector | Tissue Engineering: Stem Cells (PDF - 1.5 MB) |
| E1 | Quiz 1 | | |
| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 | Characteristics of the Surfaces of Biomaterials | Spector | Materials: Bonding and Properties (PDF)
Cell-Matrix Interactions (PDF)
Response to Particles (PDF) |
| L10 | Methodology for the Analysis of Surfaces | Spector | |
| L11 | Physicochemical Principles of Protein Adsorption on Solid Surfaces | Spector | |
| L12 | Protein/Cell/Tissue-Biomaterials Interactions | Spector | |
| L13 | Linear vs. Cooperative Cell-Matrix Interactions | Yannas | Cell-Matrix Interactions [That Determine Biomaterials Function In Vitro and In Vivo] (PDF) |
| L14 | Cell-Matrix Interactions During Spontaneous Healing | Yannas | Cell-Matrix Interactions - Part B (PDF) |
| L15 | Contraction-Blocking Theory of Regeneration in Adults | Yannas | Cell-Matrix Interactions - Part C (PDF)
A Theory of Induced Regeneration in Adults (PDF) |
| E2 | Quiz 2 | | |
| III. In Vivo and Clinical Case Studies |
| L16 | Joints and Dental Tissues: Prosthetic Replacement | Spector | Materials for Joint Replacement (PDF) |
| L17 | Joints and Dental Tissues: Regeneration 1 | Spector | Biomaterials for Joint Regeneration 1 (PDF) |
| L18 | Joints and Dental Tissues: Regeneration 2 | Spector | Dental Tissue Regeneration (PDF)
Biomaterials for Joint Regeneration 2 (PDF - 1.2 MB) |
| L19 | Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses | Spector | |
| L20 | Rules for Synthesis of Tissues and Organs | Yannas | Simplest Synthetic Pathways (PDF) |
| L21 | In Vivo Synthesis of Skin | Yannas | Methodology of Organ Synthesis (PDF) |
| L22 | In Vivo Synthesis of Peripheral Nerves | Yannas | Conjunctiva Synthesis In Vivo (Regeneration) (PDF) |
| L23 | In Vivo Synthesis of the Conjunctiva and of Kidney Tissue | Yannas | |
| E3 | Quiz 3 | | |