| 1 | Background of Protein Misfolding and Disease | |
| 2 | Origins of the Protein-only Hypothesis of Prions | |
| 3 | Controversial Evidence against the Virus-hypothesis of Prion | |
| 4 | Pathology of the Transmissible Spongiform Encephalopathies | |
| 5 | Structure of the Prion Protein | |
| 6 | The Prion Species Barrier | Assignment 2 due |
| 7 | Detection of Prion Diseases in Humans and Animals | |
| 8 | Alzheimer's Disease | |
| 9 | Transmission Electron Microscopy: Field trip to TEM facility | |
| 10 | Oligomeric Ring Structures in Alzheimer's and Parkinson's Disease | |
| 11 | Parkinson's Disease and α-synuclein | |
| 12 | Polyglutamine repeats in Kennedy's and Huntington's Diseases | |
| 13 | Senile Systematic Amyloidosis and Inflammation | Assignment 3 proposal due |